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D-2HG was found to inhibit the function of DNA and histone demethylases and was associated with altered epigenetic regulation, collagen synthesis, and cell signaling [54]

Alpha Lipoic Acid is also recognised for its ability to interact with other antioxidants, contributing to their function

doi: 10.1001/jamanetworkopen.2020.21701 [DOI] [PMC free article] [PubMed] [Google Scholar] 8

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Note that while hemoglobinemia refers to the presence of free hemoglobin in the plasma, methemoglobinemia refers to increased levels of methemoglobin within circulating RBCs

Pharmacogenetics is most often based on the cytochrome P450 enzyme system, primarily found in the liver and involves genes coding for the production of cytochrome P450 enzymes 6-9